ArticlemedRxiv : the preprint server for health sciences2025
SVEP1 Upregulation Is a Prominent Molecular Response to Dietary Sodium Loading and Correlates with Inverse Salt Sensitivity.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: While some individuals exhibit salt sensitivity, others demonstrate salt resistance or inverse salt sensitivity-blood pressure reduction during high sodium intake. The molecular mechanisms underlying heterogeneous blood pressure responses to dietary sodium remain poorly understood. Deep proteomics provides a new tool to identify molecular mediators of salt resistance and inverse salt sensitivity. Methods: We conducted a randomized crossover trial in 20 normotensive adults comparing 8-day periods of low-sodium (10 mmol/day) versus high-sodium (300 mmol/day) diets. Comprehensive plasma proteomic analysis was performed using SomaLogic's 7k proteomics platform, which measures approximately 7,000 human proteins. The change in proteins between the high- and low-sodium diets was compared with the change in blood pressure. Results: Despite average weight difference of +1.4 kg during high- versus low-sodium intake (p=8.85×10 Conclusions: SVEP1 emerges as a primary molecular correlate of blood pressure responses to dietary sodium, likely through a volume- or stretch-mediated stimulus. Given SVEP1's established functions in vascular smooth muscle relaxation and lymphangiogenesis, these findings suggest novel pathways mediating cardiovascular adaptation to sodium challenges and potential biomarkers for identifying salt-sensitive versus salt-resistant individuals.
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