Evidence map›Paper›PMID 40832361›Full record

ArticlebioRxiv : the preprint server for biology2025

G

Lucrezia Zanetti, Luca Franchini, Shirsha Saha, Yini Liao, Brian S Muntean, Cesare Orlandi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    Gα2026
5 · Who and what money

Authors and funding

6 authors.

Lucrezia ZanettiDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.
Luca FranchiniDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.
Shirsha SahaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.
Yini LiaoDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Brian S MunteanDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.ORCID 0000-0001-9090-2929
Cesare OrlandiDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0002-4992-9350

Funding

Discovery of synthetic and endogenous ligands for orphan GPCR GPR156R01DC022104 · NIDCD · UNIVERSITY OF ROCHESTER · PI Cesare Orlandi · 2024 to 2026
$2.0M
Role of KCTD proteins in striatal signalingR01NS129554 · NINDS · AUGUSTA UNIVERSITY · PI Brian S Muntean · 2023 to 2026
$1.5M
NIDCD NIH HHS R01 DC022104NINDS NIH HHS R01 NS129554
6 · The paper itself

Abstract

Dopamine receptors are G protein coupled receptors (GPCRs) that serve as key targets for FDA-approved drugs used to treat various neuropsychiatric disorders. Notably, ~11% of all marketed GPCR-targeting drugs act on dopamine receptors. Five GPCRs mediate the effects of endogenous dopamine and compounds used to treat Parkinson's disease, schizophrenia, and other conditions. However, on-target side effects associated with these medications highlight the need to analyze dopamine receptor signaling to design safer, more effective therapeutics. We characterized the G protein coupling of dopamine D2-like receptors and observed the striking inability of D3R to engage with G

Indexed as

cell-based assaysD3Rdopaminergic systemG protein-coupled receptor (GPCR)neuropharmacology

Identifiers

PMID40832361
PMCPMC12363792

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.