Evidence map›Paper›PMID 40832356›Full record

ArticlebioRxiv : the preprint server for biology2025

Disrupted Transcriptional Networks by Mutant Atrophin-1 in a Cell Culture Model of Dentatorubral-Pallidoluysian Atrophy.

Oluwademilade Nuga, Masoumeh Pourhadi, Julia P Rausch, Sokol V Todi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Oluwademilade NugaDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Masoumeh PourhadiDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Julia P RauschDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Sokol V TodiDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.ORCID 0000-0003-4399-5549

Funding

Protection against Alzheimer's Disease proteins by novel ubiquitin processesR01NS086778 · NINDS · WAYNE STATE UNIVERSITY · PI Sokol Todi · 2014 to 2026
$4.9M
NINDS NIH HHS R01 NS086778
6 · The paper itself

Abstract

Dentatorubral-Pallidoluysian Atrophy (DRPLA) is a dominant neurodegenerative disease caused by CAG triplet repeat expansion in

Indexed as

HEK293misfoldingneurodegenerationoxidative stresspolyglutaminequality controlsequencing

Identifiers

PMID40832356
PMCPMC12363894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.