Evidence map›Paper›PMID 40832353›Full record

ArticlebioRxiv : the preprint server for biology2025

Targeting FSP1 triggers ferroptosis in lung cancer.

Katherine Wu, Alec J Vaughan, Jozef P Bossowski, Yuan Hao, Aikaterini Ziogou, Seon Min Kim, Tae Ha Kim, Mari N Nakamura, Ray Pillai, Mariana Mancini and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Katherine WuDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-0472-0166
Alec J VaughanDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-0154-8911
Jozef P BossowskiDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Yuan HaoDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Aikaterini ZiogouDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0000-0028-6748
Seon Min KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
Tae Ha KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
Mari N NakamuraDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Ray PillaiDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-8335-3463
Mariana ManciniDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Sahith RajalingamDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Mingqi HanPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Toshitaka NakamuraInstitute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.ORCID 0000-0002-4248-2058
Lidong WangMoores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Suckwoo ChungDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Diane SimeoneMoores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
David ShackelfordPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Yun Pyo KangCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
Marcus ConradInstitute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Thales PapagiannakopoulosDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-2251-1624

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Medical Scientist Research Service AwardT32GM136573 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SULMAN, ERIK · 2020 to 2024
$6.8M
Identifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancerR37CA222504 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2018 to 2024
$3.3M
Training Program in Cell BiologyT32GM136542 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, SUSAN · 2020 to 2024
$3.0M
Novel approaches to target KEAP1 mutant tumorsR01CA283049 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Thales Papagiannakopoulos · 2024 to 2026
$2.0M
Investigating the therapeutic potential of a novel glutamine antagonist in KEAP1 mutant lung cancerR01CA262562 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Thales Papagiannakopoulos · 2024 to 2026
$2.0M
Uncovering Genotype Specific Vulnerabilities in KRAS Mutant Lung Cancer?R01CA227649 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2018 to 2022
$1.9M
Linear Ion Trap - Quadrupole LC-MS SystemS10OD032292 · OD · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2022 to 2022
$592k
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
Multispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359k
Dissecting the role of redox homeostasis and ferroptosis in lung cancerF30CA275258 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WU, KATHERINE · 2023 to 2025
$161k
NCI NIH HHS F30 CA275258NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA227649NCI NIH HHS R01 CA262562NCI NIH HHS R01 CA283049NCI NIH HHS R37 CA222504NCRR NIH HHS S10 RR027926NIGMS NIH HHS T32 GM136542NIGMS NIH HHS T32 GM136573NIH HHS S10 OD021747NIH HHS S10 OD032292
6 · The paper itself

Abstract

Pre-clinical and clinical studies have demonstrated how dietary antioxidants or mutations activating antioxidant metabolism promote cancer, highlighting a central role oxidative stress in tumorigenesis. However, it is unclear if oxidative stress ultimately increases to a point of cell death. Emerging evidence indicates that cancer cells are susceptible to ferroptosis, a form of cell death triggered by uncontrolled lipid peroxidation

Indexed as

ferroptosisFSP1GPX4lung cancer

Identifiers

PMID40832353
PMCPMC12363832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.