Evidence map›Paper›PMID 40832346›Full record

ArticlebioRxiv : the preprint server for biology2025

Detection of Cytosolic Ion Concentrations by the Trans-Golgi Network/Early Endosome is Important for Salt Tolerance.

Daniel McKay, Upendo Lupanga, Michelle Uebele Perez, Melanie Krebs, Stefanie Wege, Michael Grabe, Karin Schumacher

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel McKayCell Biology, Centre for Organismal Studies (COS), Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.ORCID 0000-0001-9743-4961
Upendo LupangaCell Biology, Centre for Organismal Studies (COS), Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.ORCID 0000-0001-7732-5012
Michelle Uebele PerezCell Biology, Centre for Organismal Studies (COS), Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.ORCID 0009-0001-1630-4901
Melanie KrebsCell Biology, Centre for Organismal Studies (COS), Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.ORCID 0000-0001-6858-3247
Stefanie WegeINRES, Plant Nutrition, University of Bonn, Germany.ORCID 0000-0002-7232-5889
Michael GrabeCardiovascular Research Institute and Department of Pharmaceutical Chemistry, University of California, San Francisco, United States.ORCID 0000-0003-3509-5997
Karin SchumacherCell Biology, Centre for Organismal Studies (COS), Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.ORCID 0000-0001-6484-8105

Funding

Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM137109
6 · The paper itself

Abstract

Plant survival requires cellular sensing systems that detect and respond to nutrient and ion fluctuations. The ability to monitor and adjust solute concentrations is essential for managing environmental stresses, particularly salt stress, yet the molecular mechanisms underlying cellular ion sensing remain largely unknown. Here, we combine luminal pH measurements with mathematical modelling of ion transport to investigate the role of the Trans-Golgi Network/Early Endosome (TGN/EE) for cellular ion homeostasis. Our results demonstrate that cytosolic concentrations of Cl

Identifiers

PMID40832346
PMCPMC12363952

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.