Evidence map›Paper›PMID 40832336›Full record

ArticlebioRxiv : the preprint server for biology2025

Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth.

Ting Miao, Ying Liu, Mujeeb Qadiri, John M Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ting MiaoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0634-7377
Ying LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Mujeeb QadiriDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0009-0006-9697-6447
John M AsaraMass Spectrometry Core, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA USA.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1494-1402
Xiaomei SunDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Christian DibbleDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1122-9017
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7542-472X

Funding

Regulation and Requirements for Coenzyme A BiosynthesisR01DK140239 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Christian Dibble · 2025 to 2026
$1.5M
Regulation and Requirements for Coenzyme A BiosynthesisR56DK140239 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DIBBLE, CHRISTIAN · 2024 to 2024
$676k
CANCAN ? CORNELLOT2CA278685 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2022 to 2023
$657k
NCI NIH HHS OT2 CA278685NIDDK NIH HHS R01 DK140239NIDDK NIH HHS R56 DK140239
6 · The paper itself

Abstract

Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its tissue-specific regulation and systemic physiological roles remain poorly understood. Here, using

Identifiers

PMID40832336
PMCPMC12363785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.