Evidence map›Paper›PMID 40832319›Full record

ArticlebioRxiv : the preprint server for biology2025

Serotonin selectively modulates visual responses of object motion detectors in

David J Bertsch, Lesly M Palacios Castillo, Mark A Frye

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

David J BertschDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90025-7239, USA.ORCID 0000-0001-7577-4615
Lesly M Palacios CastilloDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90025-7239, USA.
Mark A FryeDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90025-7239, USA.

Funding

Olfactory neuromodulation of visual circuits and behaviorR01NS120984 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRYE, MARK ARTHUR · 2021 to 2025
$2.1M
NINDS NIH HHS R01 NS120984
6 · The paper itself

Abstract

Serotonin (5-HT) is a hormonal messenger that confers state-level changes upon the nervous system in both humans and flies. In New & Noteworthy: How does neuromodulatory state affect visual feature detection? In this work, we demonstrate highly specific facilitated visual responses of object-detecting neurons after serotonin bath application in Drosophila. Serotonin potentiates motion-defined bar responses in object-detecting LC15 neurons and tunes response gain to translating bars of mid-range velocities in presynaptic axon terminals. Our calcium imaging extends what is known about extra-synaptic neuromodulation in the visual system and shows that serotonin heightens visual processes that inform object-specific behavior.

Indexed as

Drosophilaneuromodulationsensory processingserotoninvisual system

Identifiers

PMID40832319
PMCPMC12363769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.