Evidence map›Paper›PMID 40832307›Full record

ArticlebioRxiv : the preprint server for biology2025

Reduced efficacy of an anti-toxin vaccine from senescence-driven attenuation of toxin virulence.

Xin Du, Ching-Wen Tseng, Elisabet Bjånes, Hunter Gage, Jaclyn Swan, Chih-Ming Tsai, Irshad Hajam, Cesia Gonzalez, Brian Lin, Victor Nizet and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Xin DuDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.ORCID 0000-0002-6907-3609
Ching-Wen TsengOrca Bio, Menlo Park, California, United States.
Elisabet BjånesDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
Hunter GageDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
Jaclyn SwanDepartment of Ecological Plant and Animal Sciences, La Trobe University, Melbourne, Australia.
Chih-Ming TsaiDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
Irshad HajamDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
Cesia GonzalezDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
Brian LinDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
Victor NizetDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.
George Y LiuDepartment of Pediatrics, University of California San Diego, San Diego, California, United States.

Funding

Interrogating human anti-staphylococcal antibody responses for S. aureus vaccine insightsR01AI181321 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Clarence Buddy Creech, George Y Liu · 2023 to 2026
$3.2M
Generating protective immunity to Staphylococcus aureusR01AI127406 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI LIU, GEORGE Y, MARTINS, GISLAINE A · 2017 to 2021
$2.8M
Staphylococcus aureus interference with IsdB vaccinationR01AI144694 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIU, GEORGE Y · 2019 to 2023
$2.8M
NIAID NIH HHS R01 AI127406NIAID NIH HHS R01 AI144694NIAID NIH HHS R01 AI181321
6 · The paper itself

Abstract

It remains unclear why vaccines targeting prominent microbial virulence factors often fail in clinical trials. Because microbial virulence depends on interaction with the host immune system, we investigated how changes in host immune function alter vaccine efficacy. Using a vaccine against

Indexed as

ADAM10agedHlaimmunocompromisedS. aureussenescencevaccinevirulence

Identifiers

PMID40832307
PMCPMC12363941

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.