Evidence map›Paper›PMID 40832291›Full record

ArticlebioRxiv : the preprint server for biology2025

Contribution of HMGB1 to Keratinocyte inflammation in Recessive Dystrophic Epidermolysis Bullosa.

Kacey Guenther Bui, Ya-Chu Chang, Wannasiri Chiraphapphaiboon, Jianfeng Wang, Christen L Ebens, Anja-Katrin Bielinsky, Jakub Tolar, Hai Dang Nguyen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kacey Guenther BuiDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7384-8286
Ya-Chu ChangMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2058-3827
Wannasiri ChiraphapphaiboonMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4244-4895
Jianfeng WangDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0009-0005-8483-0654
Christen L EbensDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-2430-911X
Anja-Katrin BielinskyDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-1783-619X
Jakub TolarDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-0957-4380
Hai Dang NguyenMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4200-8778

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis BullosaR01AR063070 · NIAMS · UNIVERSITY OF MINNESOTA · PI Mark J Osborn, Jakub Tolar · 2013 to 2026
$4.5M
Mechanistic insight into genome stability pathwaysR35GM141805 · NIGMS · UNIVERSITY OF VIRGINIA · PI Anja-Katrin Bielinsky · 2021 to 2026
$2.9M
Implications of PARP1 in myelodysplastic syndromes and targeted therapyR01HL163011 · NHLBI · UNIVERSITY OF MINNESOTA · PI Dang Hai Nguyen · 2022 to 2026
$2.5M
HMGB1 in EB-Associated Squamous Cell CarcinomaF31CA281039 · NCI · UNIVERSITY OF MINNESOTA · PI Kacey Linnea Guenther Bui · 2023 to 2026
$165k
NCATS NIH HHS UL1 TR002494NCI NIH HHS F31 CA281039NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA009138NHLBI NIH HHS R01 HL163011NIAMS NIH HHS R01 AR063070NIGMS NIH HHS R35 GM141805
6 · The paper itself

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin disorder characterized by fragile skin, blistering, and chronic wounds. Keratinocytes, the primary cells in the epidermis, are directly affected by persistent injury in RDEB, contributing to chronic inflammation. High mobility group box 1 (HMGB1) is elevated in the serum of individuals with RDEB. However, its role in keratinocyte inflammation remains unclear. Here, we report an increase in

Identifiers

PMID40832291
PMCPMC12363857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.