Evidence map›Paper›PMID 40832270›Full record

ArticlebioRxiv : the preprint server for biology2025

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's Disease.

Aysegul Gungor Aydin, Pranav Manoj, Faiza Ramadan, Sarah Rajan, Elias Youssef, Elizabeth B Torres, Kasia M Bieszczad

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Aysegul Gungor AydinBiomedical Research Institute of New Jersey, Cedar Knolls, NJ, 07927, USA.ORCID 0000-0003-3398-7959
Pranav ManojRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.
Faiza RamadanDepartment of Psychology-Behavioral and Systems Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA.
Sarah RajanDepartment of Psychology-Behavioral and Systems Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA.
Elias YoussefDepartment of Psychology-Behavioral and Systems Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA.
Elizabeth B TorresComputational Biomedicine Imaging and Modelling, Rutgers University, Piscataway, Piscataway, NJ, 08854, USA.ORCID 0000-0002-4011-3611
Kasia M BieszczadDepartment of Psychology-Behavioral and Systems Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA.ORCID 0000-0002-3633-5422

Funding

Molecular epigenetic mechanisms that transform the auditory system for learning and memoryR01DC018561 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI BIESZCZAD, KASIA · 2020 to 2024
$2.2M
NIDCD NIH HHS R01 DC018561
6 · The paper itself

Abstract

Hearing has been identified as the largest modifiable mid-life risk factor for Alzheimer's Disease (AD), despite that its link to dementia remains unclear. Here we identify a biomarker of AD risk in an auditory neural signal using the non-invasive, rapidly acquired, and clinically translatable auditory brainstem response (ABR) in normal hearing knock-in rats (Swedish familial AD risk variant to

Indexed as

Alzheimer’s Diseaseauditory brainstem response (ABR)Auditory systembiomarkermemoryneuroplasticity

Identifiers

PMID40832270
PMCPMC12363771

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.