Evidence map›Paper›PMID 40832240›Full record

ArticlebioRxiv : the preprint server for biology2025

Evidence for

Renee C Geck, Melinda K Wheelock, Rachel L Powell, Ziyu R Wang, Daniel L Holmes, Shawn Fayer, Gabriel E Boyle, Allyssa J Vandi, Abby V McGee, Clara J Amorosi and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Renee C GeckUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0001-7812-7675
Melinda K WheelockUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0009-0002-9825-6276
Rachel L PowellUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0003-4791-6692
Ziyu R WangUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0009-0000-4924-2463
Daniel L HolmesUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0002-0489-4043
Shawn FayerUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0003-1883-9069
Gabriel E BoyleUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0002-2019-5787
Allyssa J VandiUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0009-0001-6781-416X
Abby V McGeeUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0001-9294-7039
Clara J AmorosiUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0002-0730-2576
Nick MooreBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3050, Australia.ORCID 0000-0001-7511-0990
Alan F RubinBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3050, Australia.ORCID 0000-0003-1474-605X
Douglas M FowlerUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0001-7614-1713
Maitreya J DunhamUniversity of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA.ORCID 0000-0001-9944-2666

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
The Center for Actionable Variant Analysis; measuring variant function at scaleUM1HG011969 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Lea Starita · 2021 to 2026
$9.9M
Comprehensive, context-aware, functional analysis of Cytochrome P450 variantsR01GM132162 · NIGMS · UNIVERSITY OF WASHINGTON · PI DUNHAM, MAITREYA J, FOWLER, DOUGLAS M · 2019 to 2022
$2.1M
Functional interpretation of human G6PD variants using multiplexed analyses in S. cerevisiaeF32GM143852 · NIGMS · UNIVERSITY OF WASHINGTON · PI GECK, RENEE CATHERINE · 2021 to 2022
$134k
NCI NIH HHS P30 CA015704NHGRI NIH HHS T32 HG000035NHGRI NIH HHS UM1 HG011969NIGMS NIH HHS F32 GM143852NIGMS NIH HHS R01 GM132162
6 · The paper itself

Abstract

G6PD deficiency is one of the most common enzyme deficiencies worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. Identifying people at risk is challenging, since most are asymptomatic until they encounter a trigger. This is further complicated since over 60% of 1,559 known genetic variants in

Identifiers

PMID40832240
PMCPMC12363787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.