Evidence map›Paper›PMID 40832228›Full record

ArticlebioRxiv : the preprint server for biology2025

Cul5

Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor, Nicholas Garaffo, David Paul Toczyski

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wilhelm Vaysse-ZinkhöferDepartment of Biochemistry, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.ORCID 0000-0001-6734-1676
Enya Marie Catherine AlcindorDepartment of Biochemistry, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Nicholas GaraffoMassachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.ORCID 0009-0005-6344-3874
David Paul ToczyskiDepartment of Biochemistry, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.ORCID 0000-0001-5924-0365

Funding

Regulation by post-translation modifications in response to stressR35GM118104 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TOCZYSKI, DAVID PAUL · 2016 to 2025
$7.2M
NIGMS NIH HHS R35 GM118104
6 · The paper itself

Abstract

Apoptosis helps eliminate damaged or unnecessary cells. Anti-apoptotic BCL2 family proteins protect cells by binding and inhibiting pro-apoptotic proteins. Our study reveals that BCL2 proteins also target Bim for degradation by serving to recruit Bim to the E3 ubiquitin ligase Cul5

Indexed as

ApoptosisCancerNeuroblastomaUbiquitinWsb2

Identifiers

PMID40832228
PMCPMC12363959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.