Evidence map›Paper›PMID 40832201›Full record

ArticlebioRxiv : the preprint server for biology2025

Newly trained navigation and verbal memory skills elicit changes in task-related networks but not brain structure.

Li Zheng, Zachary Boogaart, Andrew McAvan, Joshua Garren, Stephanie Doner, Bradley J Wilkes, Will Groves, Ece Yuksel, Lucia Cherep, Arne D Ekstrom and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Li ZhengDepartment of Psychology, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.ORCID 0000-0002-9358-4353
Zachary BoogaartThe University of Miami Miller School of Medicine, University of Miami, 1600 NW 10th Ave #1140, Miami, FL 33136.
Andrew McAvanDepartment of Psychology, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.
Joshua GarrenDepartment of Psychology, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.
Stephanie DonerDepartment of Psychology, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.
Bradley J WilkesDepartment of Applied Physiology & Kinesiology, University of Florida, 945 Center Dr., Gainesville, FL 32611.
Will GrovesDepartment of Psychology, University of Florida, 945 Center Dr., Gainesville, FL 32611.
Ece YukselDepartment of Psychology, University of Florida, 945 Center Dr., Gainesville, FL 32611.
Lucia CherepDepartment of Psychology, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.
Arne D EkstromDepartment of Psychology, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.
Steven M WeisbergDepartment of Psychology, University of Florida, 945 Center Dr., Gainesville, FL 32611.ORCID 0000-0001-7003-6082

Funding

Critical Life Event Support for K01 NIA AwardeeK01AG070333 · NIA · UNIVERSITY OF FLORIDA · PI WEISBERG, STEVEN M · 2021 to 2025
$694k
Volumetric and connectivity measures of navigation and memory skill acquisitionR21NS120237 · NINDS · UNIVERSITY OF ARIZONA · PI EKSTROM, ARNE D, WEISBERG, STEVEN M · 2020 to 2020
$434k
NIA NIH HHS K01 AG070333NINDS NIH HHS R21 NS120237
6 · The paper itself

Abstract

Training cognitive skills, such as remembering a list of words or navigating a new city, has important implications for everyday life. Yet, understanding what brain changes underlie the acquisition of complex cognitive skills remains unresolved. Here, we developed and validated intensive multiweek interventions in which participants were randomly assigned training in either navigation or verbal memory. Healthy young participants (N=75) underwent structural and functional imaging prior to and following the training. Based on pre-registered and exploratory analyses, we did not find any evidence for changes to gross hippocampal or hippocampal subfield volume, cortical brain volume, or white matter connectivity due to the training. In contrast, network-based analyses suggested changes in task-related informational connectivity, which occurred primarily between cortical areas and mostly involved putative cognitive control networks. These results suggest that cognitive interventions target more transient configurations in network connectivity rather than more durable structural changes.

Identifiers

PMID40832201
PMCPMC12363783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.