Visualising sub-second dynamics of nanoparticle extravasation

Guoying Wang, Yueying Cao, Jia Li, Xianlin Zheng, Peng Ren, Marco Morsch, Bingyang Shi, Yiqing Lu

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guoying WangMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

Yueying CaoSchool of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales 2109, Australia.

Jia LiMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

Xianlin ZhengSchool of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales 2109, Australia.

Peng RenSchool of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales 2109, Australia.

Marco MorschMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

Bingyang ShiMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

Yiqing LuSchool of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales 2109, Australia.ORCID 0000-0001-6584-1853

Funding

In vivo characterization of the molecular drivers of biomolecular condensate formation in TDP-43 neuropathologyR21DA056320 · NIDA · MACQUARIE UNIVERSITY · PI MORSCH, MARCO · 2022 to 2023

$292k

NIDA NIH HHS R21 DA056320

6 · The paper itself

Abstract

Altered vascular integrity is a hallmark for many diseases. Monitoring vascular permeability, including its extent and underlying transport pathways, is thus important for advancing our understanding of disease mechanisms towards innovative diagnosis and treatment. Here we show real-time fluorescence imaging using lanthanide-based upconversion nanoparticles as contrast agents to visualise subtle changes to vascular permeability

Identifiers

PMID40832182

DOI10.1101/2025.08.10.669578

PMCPMC12363862

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.