A prevalent huge phage clade in human and animal gut microbiomes.

LinXing Chen, Antonio Pedro Camargo, Yiting Qin, Eugene V Koonin, Haoyu Wang, Yuanqiang Zou, Yi Duan, Hao Li

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

LinXing ChenState Key Laboratory of Advanced Environmental Technology, the Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei, China.ORCID 0000-0003-2774-1952

Antonio Pedro CamargoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-060, Brazil.ORCID 0000-0003-3913-2484

Yiting QinState Key Laboratory of Advanced Environmental Technology, the Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei, China.

Eugene V KooninComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-3943-8299

Haoyu WangState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.

Yuanqiang ZouState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0000-0003-2380-264X

Yi DuanNational Key Laboratory of Immune Response and Immunotherapy, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Hao LiState Key Laboratory of Advanced Environmental Technology, the Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huge phages are widespread in the biosphere, yet their prevalence and ecology in the human gut remain poorly characterized. Here, we report Jug (Jumbo gut) phages with genomes of 360-402 kilobase pairs that comprise ~1.1% of the reads in human gut metagenomes, and are predicted to infect

Indexed as

Gut microbiomesHuge phagesJumbo phagesMetagenomicsViruses

Identifiers

PMID40832181

DOI10.1101/2025.08.10.669567

PMCPMC12363816

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