ArticlebioRxiv : the preprint server for biology2025
Translational control of innate barrier defense by the gut microbiota.
Yun Li, Runrun Wu, Xianda Ma, Jianglin Zhang, Junjie Ma, Yiran Duan, Brian Hassell, Kelly A Ruhn, Cassie L Behrendt, Chaitanya Dende and 5 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Yun LiDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Runrun WuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xianda MaDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Junjie MaDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Yiran DuanDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Brian HassellDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-0031-2173 Kelly A RuhnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-9440-8546 Cassie L BehrendtDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Chaitanya DendeDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Li WangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Andrew LemoffDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-4943-0170 Prithvi RajDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-4068-4358 Zheng KuangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2759-4641 Funding
Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9MMicrobial regulation of mammalian circadian rhythms and the sexual dimorphism: from metabolism to immunityDP2DK136278 · NIDDK · CARNEGIE-MELLON UNIVERSITY · PI KUANG, ZHENG · 2022 to 2025
$2.3MMicrobiota-dependent Epigenetic Regulation of Circadian Rhythms in Nutrient Uptake and Energy HomeostasisR00DK120897 · NIDDK · CARNEGIE-MELLON UNIVERSITY · PI KUANG, ZHENG · 2021 to 2023
$735kMicrobiota-dependent Epigenetic Regulation of Circadian Rhythms in Nutrient Uptake and Energy HomeostasisK99DK120897 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KUANG, ZHENG · 2019 to 2020
$182kNIDDK NIH HHS DP2 DK136278NIDDK NIH HHS K99 DK120897NIDDK NIH HHS R00 DK120897NIDDK NIH HHS R01 DK070855
6 · The paper itselfAbstract
The intestinal epithelium is protected by a mucus barrier, infused with antimicrobial proteins, that restricts microbial access to host tissue. Because assembling this barrier is energetically costly, its production must be tightly regulated. Here, we show that the microbiota regulates the translation of key mucus barrier components, including the structural glycoprotein mucin 2 and the antimicrobial enzyme lysozyme. This process is initiated by microbial induction of histone deacetylase 5 (HDAC5) in secretory epithelial cells of the intestine. HDAC5 promotes deacetylation of 14-3-3 proteins, enabling activation of the energy sensing kinase mTOR which enhances translation of mucus and antimicrobial proteins. These findings reveal a mechanism by which the microbiota controls barrier immunity at the level of protein synthesis and suggest that the HDAC5-mTOR axis integrates microbial and energetic signals to regulate intestinal defense.
Identifiers
PMID40832175
PMCPMC12363781
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