Evidence map›Paper›PMID 40832169›Full record

ArticlebioRxiv : the preprint server for biology2025

Revisiting Amplitude of Low-Frequency Fluctuations (ALFF) in Resting-state fMRI: Clarifications and Improvements.

Lejian Huang, Rami Jabakhanji, Andrew D Vigotsky, Paulo Branco, Marwan N Baliki, A Vania Apkarian

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lejian HuangDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-1753-2372
Rami JabakhanjiDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Andrew D VigotskyDepartments of Biomedical Engineering and Statistics & Data Science, Northwestern University, Evanston, IL 60208, USA.
Paulo BrancoCenter for Translational Pain Research, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Marwan N BalikiCenter for Translational Pain Research, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
A Vania ApkarianDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Funding

Rodent Behavior CoreP50DA044121 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2018 to 2022
$9.0M
NIDA NIH HHS P50 DA044121
6 · The paper itself

Abstract

The amplitude of low-frequency fluctuations (ALFF) and its related measure, fractional ALFF (fALFF), are widely used resting-state fMRI techniques for quantifying spontaneous neural activity within specific frequency bands. However, inconsistencies in the definition and implementation of ALFF have led to confusion in the field. In this study, we provide a mathematical clarification of ALFF and fALFF by introducing two variants: the arithmetic mean-defined ALFF/fALFF (amALFF/amfALFF) and the quadratic mean-defined ALFF/fALFF (qmALFF/qmfALFF). We examine the relationships between mean BOLD intensity (MBI), amALFF, and qmALFF across both subjects and voxels using two independent datasets mapped onto different brain templates. Additionally, we investigate the impact of

Indexed as

BOLD intensityfMRIqmALFFqmfALFFspontaneous neural activityz-scoring

Identifiers

PMID40832169
PMCPMC12363799

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.