Evidence map›Paper›PMID 40832162›Full record

ArticlebioRxiv : the preprint server for biology2025

Immune dysregulation in the prostates of C57BL/6

Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Nadia A LanmanDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-1819-7070
Meaghan M BromanDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.
Harish KothandaramanPurdue University Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.
Gregory M CresswellDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.
Gada D AwdalkreemDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.
Dilinaer WusimanDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.
Andree K KolliegboPurdue University Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.
Alexander P GlaserDivision of Urology, Department of Surgery, Endeavor Health Research Institute, Evanston, IL 60201.
Brian T HelfandDivision of Urology, Department of Surgery, Endeavor Health Research Institute, Evanston, IL 60201.
Renee E VickmanUniversity of Chicago Pritzker School of Medicine, Chicago, IL, 60637.
Jiang YangDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.
Simon W HaywardUniversity of Chicago Pritzker School of Medicine, Chicago, IL, 60637.ORCID 0000-0002-6059-6550
Timothy L RatliffDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Impact of Inflammation on Adult Prostate Stem CellsR01DK126478 · NIDDK · PURDUE UNIVERSITY · PI RATLIFF, TIMOTHY L. · 2020 to 2023
$2.4M
Validating Mouse Models of Prostatic HyperplasiaP20DK140417 · NIDDK · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI Simon W Hayward · 2024 to 2026
$1.6M
NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NIDDK NIH HHS P20 DK140417NIDDK NIH HHS R01 DK126478
6 · The paper itself

Abstract

Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH. BPH is highly complex and heterogeneous, presenting with varying degrees of stromal and epithelial proliferation, fibrosis, inflammation and associated lower urinary tract symptoms. This complexity presents challenges in developing models. Here, we characterize an

Indexed as

AireBPHinflammationprostatescRNA-seq

Identifiers

PMID40832162
PMCPMC12363768

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.