ArticleFrontiers in neurology2025
Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Histological Insights into the Neuroprotective Effects of Antioxidant Peptides and Small Molecules in Cerebral Ischemia.Molecules (Basel, Switzerland) · 2025Pooled it
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Authors and funding
28 authors.
Funding
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Abstract
Background: Thrombus burden considerably impacts ischemic stroke presentation and outcomes. However, the relationship between thrombus histology and volume has not been studied well. We investigated whether ischemic stroke thrombus composition and spatial distribution patterns differed with thrombus volume. Methods: We enrolled patients with thrombi undergoing endovascular therapy (EVT) between July 2017 and July 2023. Thrombus volume on thin-section non-contrast computed tomography was measured using three-dimensional software. Immunohistochemistry analysis included fibrin, red blood cells (RBCs), and platelets. Thrombi were classified based on the overall distribution pattern of the components: layered, erythrocytic, mixed, and diffuse platelet. We analyzed the association between thrombus volume, histopathology, distribution patterns, and clinical/radiologic outcomes. Results: Among 210 patients, the median (interquartile range) thrombus volume was 43.7 (23.5, 74.5) mm Conclusion: Large thrombi had increased RBC proportions and a mixed pattern. RBC incorporation significantly contributes to the volumetric growth of thrombi and their fragmentation susceptibility. These findings may provide additional clue for tailoring EVT strategies.
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