Evidence map›Paper›PMID 40832141›Full record

ArticleFrontiers in cardiovascular medicine2025

Coronary artery calcium and cardiovascular risk factors analysis after radiotherapy for breast cancer (the CLARIFIER: a gender-based preventive medicine study).

Daniela Trabattoni, Maria Cristina Leonardi, Maria Elisabetta Mancini, Barbara A Jereczek-Fossa, Federica Cattani, Giulia Santagostino Baldi, Alice Bonomi, Arianna Galotta, Saima Mushtaq, Andrea Annoni and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05775822 (Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT for Breast Cancer. A Gender-based Preventive Medicine Approach), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05775822 nacompletednot on this map

Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT for Breast Cancer. A Gender-based Preventive Medicine Approach

TypeinterventionalSponsorCentro Cardiologico MonzinoRan2022 to 2024Enrolled92ConditionsBreast CancerArmsCT scan and blood sample collection
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Stereotactic radioablation for ventricular tachycardia in patients untreatable by catheter ablation: evidence of efficacy, safety, and impact on coronary arteries.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniela TrabattoniCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Maria Cristina LeonardiDivision of Radiation Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Maria Elisabetta ManciniCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Barbara A Jereczek-FossaDivision of Radiation Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Federica CattaniUnit of Medical Physics, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Giulia Santagostino BaldiCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Alice BonomiCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Arianna GalottaCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Saima MushtaqCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Andrea AnnoniCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Davide AlioDivision of Radiation Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Maria Giulia VinciniDivision of Radiation Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Cristiana Iuliana FodorDivision of Radiation Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Ludovico La GruttaBiomedicine, Neuroscience and Advanced Diagnostics (BiND) Department, University of Palermo, Palermo, Italy.
Piero MontorsiCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Gianluca PontoneCentro Cardiologico Monzino, IRCCS, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients receiving thoracic radiation (RT) are at increased risk for heart disease. Coronary artery calcium (CAC) is an independent risk factor for cardiac events. Aim: The aim of this prospective, joint-institution, study was to analyze the relationship between cardiovascular risk factors (CVRF) known before breast cancer diagnosis and treatment, and the risk of developing coronary events in women undergoing adjuvant breast radiotherapy by measuring CAC. Methods: Women ( Results: Data obtained from 91/92 patients, showed a 36.2% incidence of pathologic Agatston CAC score, independent of the irradiated breast side. After grouping patients according to the total number of CVRF [group 1, Conclusion: This study helps to identify women at high-risk for cardiovascular events before RT and implement the best possible prevention of late post cancer treatment events. Clinical Trial Registration: ClinicalTrials.gov, Identifier (NCT05775822).

Indexed as

breast cancercoronary artery calciumcoronary diseaseCV riskspreventionradiation therapy

Identifiers

PMID40832141
PMCPMC12359178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.