Evidence map›Paper›PMID 40832126›Full record

ArticleFrontiers in neural circuits2025

Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution.

Sakiko Tsugawa, Yuichi Kimura, Junichi Chikazoe, Hiroki Abe, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Hiroyuki Uchida, Tomoyuki Miyazaki, Yuuki Takada and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neural circuits, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Sakiko TsugawaDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Yuichi KimuraFaculty of Informatics, Cyber Informatics Research Institute, Kindai University, Higashi-Osaka, Japan.
Junichi ChikazoeBrain, Mind and KANSEI Sciences Research Center, Hiroshima University, Hiroshima, Japan.
Hiroki AbeDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Tetsu ArisawaRadioisotope Research Center, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Mai HatanoDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Waki NakajimaDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Tomoyuki MiyazakiDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Yuuki TakadaDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Akane SanoDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Kotaro NakanoDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Tsuyoshi EiroDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Akira SudaDepartment of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Takeshi AsamiDepartment of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Akitoyo HishimotoDepartment of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
Hideaki TaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Nobuhiro NagaiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Teruki KoizumiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Shunya KurokawaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Yohei OhtaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Kie TakahashiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Yuhei KikuchiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Taisuke YatomiDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Ryo MitomaDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
Shunsuke TamuraDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
Shingo BabaDepartment of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Osamu TogaoDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoji HiranoDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
Hirotaka KosakaDepartment of Neuropsychiatry, School of Medical Sciences, University of Fukui, Fukui, Japan.
Hidehiko OkazawaBiomedical Imaging Research Center, University of Fukui, Fukui, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Takuya TakahashiDepartment of Physiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An accurate diagnostic method using biological indicators is critically needed for bipolar disorder (BD) and major depressive disorder (MDD). The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a crucial regulator of synaptic function, and its dysregulation may play a central role in the pathophysiology of psychiatric disorders. Our recently developed positron emission tomography (PET) tracer, [

Indexed as

Bipolar DisorderBrainMajor Depressive DisorderReceptors, AMPAAdultDiagnosis, DifferentialFemaleHumansMachine LearningMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyYoung AdultReceptors, AMPAAMPA receptorbipolar disorderdepressiondifferentiationmachine learning

Identifiers

PMID40832126
PMCPMC12358400

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.