Evidence map›Paper›PMID 40832112›Full record

ArticleIBRO neuroscience reports2025

Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study.

Ling Wang, Beining Yang, Qunya Qi, Haotian Xin, Yu Wang, Yulong Jia, Qian Chen, Weimin Zheng, Xin Chen, Tengfei Liang and 5 more

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In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ling WangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Beining YangDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qunya QiDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Haotian XinDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yu WangDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yulong JiaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qian ChenDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Weimin ZhengDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xin ChenDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Tengfei LiangDepartment of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, China.
Chuchu SunDepartment of Nuclear Medicine, Beijing Electric Power Hospital, Beijing, China.
Jubao DuDepartment of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Baowei LiDepartment of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, China.
Jie LuDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Nan ChenDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To study the brain functional alterations of children after spinal cord injury (SCI) and explore their changes after motor imagery training (MIT), revealing brain functional reorganizations in pediatric SCI and finding possible neural mechanisms of MIT. Thirty pediatric SCI patients and 30 age- and gender-matched healthy controls (HCs) were recruited. Brain resting-state functional MRI images of all subjects were obtained using a 3.0 Tesla MRI system. Subsequently, eight of the patients completed a 4-week MIT, and then functional MRI scans were conducted once again. Then two-sample t-tests were used to compare amplitude of low frequency (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) between groups at baseline, and paired t-tests were used to investigate the changes in ALFF, fALFF and ReHo of patients before and after the treatment. Compared with HCs, the patients showed decreased ALFF and/or ReHo in bilateral postcentral gyrus (S1) and right orbitofrontal cortex, while increased ALFF and/or ReHo in the bilateral cerebellar lobules IV-VI, thalamus, left middle cingulate cortex (MCC), cerebellar Crus II, and right parahippocampal gyrus, caudate nucleus, middle temporal gyrus (MTG). Compared with those before MIT, the patients showed significantly increased ALFF in the right S1 after the treatment. These findings demonstrated brain functional reorganization in sensoriomotor, cognitive-emotional and auditory/language related regions, and MIT may promote the rehabilitation by reversing the functionally reorganized sensoriomotor areas, which may provide a possible mechanism for MIT.

Indexed as

Brain functional reorganizationMagnetic resonance imagingMotor imagery trainingPediatricSpinal cord injury

Identifiers

PMID40832112
PMCPMC12359259

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