Evidence map›Paper›PMID 40832101›Full record

ArticleFrontiers in medicine2025

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux.

Chenglin Jia, Biying Hong, Yujie Jiang, Chao Ma, Wei Liu, Yicheng Xu, Jian Chen, Yan Xie, Guangbo Ge, Ye-Min Cao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenglin Jia *Shanghai TCM-Integrated Hospital, Institute of Vascular Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Biying Hong *Department of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Yujie JiangDepartment of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Chao MaShanghai TCM-Integrated Hospital, Institute of Vascular Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei LiuShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yicheng XuShanghai TCM-Integrated Hospital, Institute of Vascular Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jian ChenShanghai TCM-Integrated Hospital, Institute of Vascular Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan XieShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Guangbo GeShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ye-Min CaoShanghai TCM-Integrated Hospital, Institute of Vascular Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tianhua YanDepartment of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Yongbing CaoShanghai TCM-Integrated Hospital, Institute of Vascular Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the study: To investigate the effect of Ruanjian Qingmai granules (RJQM) on arteriosclerotic obliterans (ASO) and identify its potential bioactive components. Materials and methods: Separate zebrafish atherosclerosis models and cellular lipid metabolism disorder models were established, and RJQM was administered at different concentrations for intervention. The lipid deposition was examined by using Nile Red staining. The expression levels of cholesterol metabolism-related genes were determined by using quantitative real-time PCR (qRT-PCR). The Results: Ruanjian Qingmai granules significantly decreased lipid deposition and significantly increased the expression of Conclusion: Ruanjian Qingmai granules exerts a therapeutic effect on ASO by up-regulating the expression level of

Indexed as

arteriosclerosis obliteransCYP7A1lipid reprogrammingpotential bioactive componentsRuanjian Qingmai granules

Identifiers

PMID40832101
PMCPMC12358959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.