ArticleFrontiers in public health2025
A study on the distribution of interleukin-10 gene polymorphisms and their association with febrile seizure susceptibility in children from the Wenzhou region, Zhejiang Province.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Immunological mechanisms and prevention strategies for febrile seizures in children.Frontiers in immunology · 2026Review
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6 authors.
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Abstract
Background: Febrile seizures (FS) were the most common seizure disorder in young children, with a notable prevalence in the Zhejiang Province region of China. The pathogenesis of FS involves both genetic and environmental factors, particularly the role of cytokines like Interleukin-10 (IL-10), an anti-inflammatory agent. This study examines the distribution of IL-10 gene polymorphisms and their association with FS susceptibility in children from Wenzhou, Zhejiang Province. Methods: This retrospective study included 77 pediatric patients with FS and a control group of 71 healthy children. The FS group was divided into simple FS (SFS) and complex FS (CFS) subgroups. IL-10 gene polymorphisms at loci 1,082 (rs1800896 G/A), 819 (rs1800871 C/T), and 592 (rs1800872 A/C) were analyzed. IL-10 expression levels were measured, and association with FS susceptibility was evaluated using statistical methods including logistic regression. Results: IL-10 expression levels were significantly reduced in children with FS (mean: 3.42 ± 1.27 pg./mL) compared to controls (mean: 3.87 ± 1.16 pg./mL; Conclusion: Reduced IL-10 levels and specific IL-10 gene polymorphisms, particularly rs1800896 and rs1800872, were associated with increased susceptibility to febrile seizures in children from Wenzhou. These findings may inform early diagnostic markers, risk stratification tools, and potentially guide personalized treatment strategies for children at higher risk of FS.
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