Evidence map›Paper›PMID 40831870›Full record

ReviewCureus2025

Health Literacy and Medication Adherence in Polypharmacy: A Systematic Review for Clinical Practice.

Inês Jordão, Patrícia Paiva, Patrícia Dias, Natália António, Francisco Parente

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. [Development and reliability and validity testing of the Medication Literacy Scale for patients with chronic heart failure].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Inês JordãoFaculty of Medicine, University of Coimbra, Coimbra, PRT.
Patrícia PaivaClinical Pharmacology Unit, Local Health Unit of Coimbra, Coimbra, PRT.
Patrícia DiasClinical Pharmacology Unit, Local Health Unit of Coimbra, Coimbra, PRT.
Natália AntónioClinical Pharmacology Unit, Local Health Unit of Coimbra, Coimbra, PRT.
Francisco ParenteClinical Pharmacology Unit, Local Health Unit of Coimbra, Coimbra, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Health literacy (HL) is a critical but often overlooked factor in medication adherence, particularly for polypharmacy patients. Despite 387 studies on adherence published since 2019, only 12% examined HL as a primary variable. To synthesize evidence on the impact of HL levels on medication use and adherence. We conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guided review of 16 studies (2019-2024) from PubMed, Scopus, and SciELO, focusing on HL tools and adherence measures. Low HL (LHL) had a 2.6 times higher rate of unintentional non-adherence and 68% more misinterpretations of prescriptions (p < 0.01). Pharmacist-led interventions and the use of visual schemes increased adherence and reduced dosage errors by up to 52%. Patients with LHL showed 35% more hospital readmissions within 30 days. HL screening should be integrated into polypharmacy management protocols. Policy-makers must prioritize HL-sensitive interventions to reduce avoidable costs.

Indexed as

clinical interventionshealthcare costshealth literacyhealth outcomesmedication adherencepatient educationpolypharmacy

Identifiers

PMID40831870
PMCPMC12360272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.