Evidence map›Paper›PMID 40831854›Full record

ReviewCureus2025

AI-Driven Neonatal MRI Interpretation: A Systematic Review of Diagnostic Efficiency, Prognostic Value, and Implementation Barriers for Hypoxic-Ischemic Encephalopathy.

Rajeshwari A V, Sandhya Rao D, Pranahitha Bantu, Rakesh Kotha

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajeshwari A VRadiodiagnosis, Gandhi Medical College, Hyderabad, IND.
Sandhya Rao DRadiodiagnosis, Gandhi Medical College, Hyderabad, IND.
Pranahitha BantuRadiodiagnosis, Osmania Medical College, Hyderabad, IND.
Rakesh KothaNeonatology, Osmania Medical College, Hyderabad, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI), especially deep learning techniques, is revolutionizing neonatal neuroimaging by significantly improving the detection and prognostic evaluation of hypoxic-ischemic encephalopathy (HIE), a major contributor to neonatal morbidity and mortality. This systematic review integrates findings from five high-quality, peer-reviewed studies published between 2015 and 2025, identified through comprehensive searches of PubMed, Embase, Scopus, and the Cochrane Library. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and applied the Newcastle-Ottawa Scale (NOS), Risk of Bias 2 (RoB 2), and Assessment of Multiple Systematic Reviews 2 (AMSTAR 2) tools to ensure methodological rigor and minimize bias. AI algorithms, especially convolutional neural networks (CNNs), have shown high effectiveness in identifying brain injuries associated with HIE, with sensitivity ranging from 83% to 95% and specificity between 86% and 93%. These models frequently outperform conventional radiological assessments in diagnostic accuracy. These models also reduced interpretation time by up to 47%, streamlining critical care workflows. Prognostic AI tools showed 77-87% accuracy in predicting long-term neurodevelopmental outcomes, aiding in early clinical interventions and family guidance. Despite these promising results, limitations such as small sample sizes (n = 100-200), heterogeneous MRI protocols, and high computational demands hinder broader clinical application. Standardized imaging, multi-center collaboration, and explainable AI models are crucial for clinical scalability. Moreover, successful integration of AI into neonatal intensive care units (NICUs) requires rigorous validation, ethical oversight, and clinician training to ensure safety, transparency, and trust. Collaborative efforts between neonatologists, radiologists, data scientists, and policymakers will be essential to align AI innovations with patient-centered care. As this technology matures, it holds significant potential to improve diagnostic precision, optimize clinical outcomes, and reduce disparities in neonatal neurological care.

Indexed as

artificial intelligence (ai)convolutional neural networkshypoxic-ischemic encephalopathyneonatal mrineurodevelopmental prognosisntraventricular hemorrhagewhite matter damage

Identifiers

PMID40831854
PMCPMC12359275

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.