ArticleCureus2025
Eosinophilic Granulomatosis With Polyangiitis (EGPA) Hidden in Acute Appendicitis: A Case Revealed Through Histopathological Examination.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of necrotising vasculitis characterised by eosinophilic infiltration and systemic involvement, most commonly affecting the lungs, skin, and peripheral nerves. Gastrointestinal (GI) manifestations are common in patients with EGPA, although histopathological confirmation of GI involvement is infrequent. Acute appendicitis is a common surgical emergency, but its presentation as an initial manifestation of EGPA is exceptionally uncommon. We report the case of a 54-year-old man with a history of asthma who presented with fever and epigastric pain that later migrated to the right lower quadrant. Laboratory tests revealed leukocytosis and elevated C-reactive protein levels. Abdominal computed tomography (CT) demonstrated mild appendiceal enlargement, and a diagnosis of acute appendicitis was made. The patient underwent laparoscopic appendectomy. Postoperatively, he developed persistent lower abdominal pain, new-onset bilateral lower extremity pain, and marked eosinophilia (60%). Histopathological examination of the resected appendix revealed dense eosinophilic infiltration and necrotising vasculitis, establishing the diagnosis of ANCA-negative EGPA. This phenotype is known to present with gastrointestinal manifestations and peripheral eosinophilia frequently. He was subsequently transferred to a specialised centre for further treatment. This case highlights the potential for EGPA to mimic acute appendicitis. When persistent eosinophilia and atypical postoperative symptoms are present, systemic diseases such as EGPA should be considered. Histopathological analysis plays a pivotal role in identifying underlying systemic vasculitis, particularly in cases with unusual clinical presentations. Greater awareness of EGPA as a differential diagnosis in atypical appendicitis may facilitate earlier recognition and timely management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.