Progress of ketogenic diet in the treatment of developmental epileptic encephalopathy.

Wandong Hu, Lili Li, Fen Zhao, Huan Zhang, Hongwei Zhang

Abstract readReview

In one paragraph

Review in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Managing Drug-Resistant Epilepsy and Severe Feeding Difficulties in Miller-Dieker Syndrome: The Role of Enteral Ketogenic Diet.Case reports in pediatrics · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wandong Hu *Department of Neurology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Lili Li *Department of Neurology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Fen ZhaoDepartment of Neurology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Huan ZhangDepartment of Neurology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Hongwei ZhangDepartment of Neurology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developmental epileptic encephalopathy (DEE) is a severe neurological disorder caused by underlying genetic abnormalities and frequent epileptic activity. It is characterized by early-onset, drug-resistant epilepsy, abnormal electroencephalogram (EEG) findings, and developmental delay or regression. DEE is associated with high rates of disability and mortality. The ketogenic diet (KD) is a well-established non-pharmacological treatment for refractory epilepsy and has demonstrated therapeutic efficacy in several DEE subtypes. In certain cases, it may reduce or even eliminate the need for pharmacological interventions. This review discusses the current clinical application of KD in children with DEE and summarizes key factors influencing its therapeutic effectiveness.

Indexed as

developmental delaydevelopmental epileptic encephalopathyearly-onset drug-refractory epilepsyketogenic dietrefractory epilepsy

Identifiers

PMID40831798

DOI10.3389/fped.2025.1567095

PMCPMC12358386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.