Case Report: From IgA nephropathy to pneumonia, periappendiceal abscess, pulmonary arterial hypertension, and basal ganglia calcification: a case of chronic active Epstein-Barr infection in a child.

Shuying Fan, Xin Wang, Ning Wei, Qiumei Zhou, Wenhong Wang

Abstract readCase Reports

In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Shuying FanDepartment of Nephrology, Tianjin Children's Hospital, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.

Xin WangDepartment of Nephrology, Tianjin Children's Hospital, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.

Ning WeiDepartment of Nephrology, Tianjin Children's Hospital, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.

Qiumei ZhouDepartment of Nephrology, Tianjin Children's Hospital, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.

Wenhong WangDepartment of Nephrology, Tianjin Children's Hospital, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic active Epstein-Barr virus infection (CAEBV) is a lymphoproliferative disorder characterized by persistent EBV infection, which can lead to multi-organ involvement. This case describes a child with CAEBV who initially presented with IgA nephropathy (IgAN) without characteristic infectious mononucleosis (IM) features. The patient initially presented with intermittent gross hematuria, Renal biopsy confirmed focal proliferative IgAN, and the child was treated with methylprednisolone pulse therapy followed by oral prednisone. During follow-up, the patient sequentially developed pneumonia caused by co-infection with EBV and

Indexed as

childchronic active Epstein–Barr infectionenteritisIgA nephropathypneumoniapulmonary arterial hypertension

Identifiers

PMID40831797

DOI10.3389/fped.2025.1589151

PMCPMC12358464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.