Evidence map›Paper›PMID 40831772›Full record

ArticleTrauma surgery & acute care open2025

Does mean arterial pressure augmentation improve neurological recovery of blunt spinal cord injuries: an EAST multicenter trial.

Aimee LaRiccia, Stephanie Doris, Bhairav Shah, Tanisha Kashikar, Erik Teicher, Lindsey Perea, Jennifer Huber, Malia Eischen, H Akin Erol, Michael Steven Farrell and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trauma surgery & acute care open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Aimee LaRicciaOhioHealth, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-7663-4734
Stephanie DorisOhioHealth, Columbus, Ohio, USA.
Bhairav ShahOhioHealth, Columbus, Ohio, USA.
Tanisha KashikarOhioHealth, Columbus, Ohio, USA.
Erik TeicherSurgery, Inova Fairfax Medical Center, Falls Church, Virginia, USA.
Lindsey PereaSurgery, Division of Trauma and Acute Care Surgery, Lancaster General Health, Lancaster, Pennsylvania, USA.
Jennifer HuberLancaster General Health, Lancaster, Pennsylvania, USA.
Malia EischenQueen's Medical Center, Honolulu, Hawaii, USA.
H Akin ErolQueen's Medical Center, Honolulu, Hawaii, USA.
Michael Steven FarrellSurgery, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-7665-2775
Lauren ColomLehigh Valley Health Network, Allentown, Pennsylvania, USA.
Stephanie ScottThe University of Tennessee Medical Center, Knoxville, Tennessee, USA.
Brian DaleySurgical Critical Care, University of Tennessee Medical Center, Knoxville, Tennessee, USA.ORCID https://orcid.org/0000-0002-4996-1502
James BardesTrauma, Acute Care and Critical Care, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, West Virginia, USA.
Gregory SchaeferTrauma, Acute Care Surgery and Critical Care, West Virginia University Health Sciences Center, Morgantown, West Virginia, USA.
Melissa MoncriefTrauma, Kettering Health Main Campus, Kettering, Ohio, USA.ORCID https://orcid.org/0000-0002-3378-9162
William DeVoeRiverside Methodist Hospital, Columbus, Ohio, USA.
Ryan Peter DumasUT Southwestern Medical, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-6566-1833
Caitlin Anne FitzgeraldEast Carolina University, Greenville, North Carolina, USA.ORCID https://orcid.org/0009-0006-8178-5285
William BrigodeCook County Health, Chicago, Illinois, USA.
John D BerneTrauma Surgery, Broward Health Medical Center, Fort Lauderdale, Florida, USA.
Dalier R MederosTrauma Serevices, Broward Health, Fort Lauderdale, Florida, USA.
Scott ArmenSurgery, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-2982-8306
Melissa Linskey DoughertySurgery, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
Asanthi RatnasekeraTrauma, ChristianaCare, Wilmington, Delaware, USA.ORCID https://orcid.org/0000-0003-4618-088X
Emily AlbertoTrauma, ChristianaCare, Wilmington, Delaware, USA.
Alison SmithTrauma, Critical Care and Acute Care Surgery, Louisiana State University Medical Center, Shreveport, Louisiana, USA.
Bradley M DennisSugery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-2419-2102
Stephen GadomskiVanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeffry NahmiasUC Irvine Healthcare, Orange, California, USA.ORCID https://orcid.org/0000-0003-0094-571X
Claudia AlvarezUC Irvine Healthcare, Orange, California, USA.
Salina WydoCooper University Hospital Regional Trauma Center, Camden, New Jersey, USA.
Jennifer SchweinsburgCooper University Hospital Regional Trauma Center, Camden, New Jersey, USA.
Carlos H PalacioSouth Texas Health System, Edinburg, Texas, USA.
M Chance SpaldingTrauma and Surgical Critical Care, Mount Carmel Hospital, Columbus, Ohio, USA.
Joshua HillOhioHealth, Columbus, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Treatment of blunt traumatic spinal cord injuries (SCIs) often includes maintaining elevated mean arterial blood pressures (MAP) to enhance perfusion to the spinal cord. Optimal hyperperfusion protocols and treatment algorithms have yet to be delineated due to a paucity of large volume prospective studies. This study aims to identify predictors of neurological improvement in American Spinal Injury Association (ASIA) impairment score following blunt SCI. Study design: Prospective (January 10, 2021 to June 1, 2023) multicenter study included blunt SCI patients age >18 with complete neurological examination documented on hospital arrival. Patients were divided into two groups: neurological improvement and no improvement, based on their change in ASIA score from arrival to hospital discharge. Results: A total of 19 centers contributed 222 patients of those, 164 had pre-ASIA and post-ASIA scores. The ASIA improvement group had 36 patients (22%). There was no statistical difference in the median percentage of time patients spent at a MAP >85 mm Hg during treatment 80.7% (IQR 63.6, 93.4) no improvement vs 83.6% (IQR 70.1, 93.0) in the improvement, (p=0.87). There was no difference in the median duration of MAP treatment in hours between the groups (95.6 hours (IQR 62.55, 113.48) in the no improvement group versus 96 (IQR 72, 113.5) (p=0.40) in the improvement group). Conclusions: Overall, 22% of all blunt SCI patients saw an improvement in their ASIA score. Adherence to and length of MAP augmentation was not a statistically significantly different between groups. Level of evidence: Level IV Therapeutic/Care Management.

Indexed as

Spinal Cord Injuries

Identifiers

PMID40831772
PMCPMC12359463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.