ArticleBioactive materials2025
Stable, bioactive hydrogel coating on silicone surfaces for non-invasive decontamination via photochemical treatment.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Polydimethylsiloxane (PDMS) is widely used in biomedical applications due to its biocompatibility, chemical stability, flexibility, and resistance to degradation in physiological environments. However, its intrinsic inertness limits further (bio)functionalization, and its hydrophobic recovery compromises the longevity of conventional surface modifications. To address these challenges, we developed a nanoprecipitation method for the straightforward colloidal deposition, covalent thermal crosslinking, and surface anchoring of a chemically tunable, biocompatible polyacrylamide with reactive hydroxyl groups, enabling further surface modifications. This polymer incorporates ∼6 % bioinspired catechol units, introduced via an elegant one-pot Kabachnik-Fields reaction, to facilitate thermally induced network formation and enhance adhesion to plasma-activated PDMS. The resulting uniform coatings exhibited tunable dry layer thicknesses up to 44 ± 7 nm and effectively suppressed PDMS chain rearrangement even after steam autoclaving, ensuring long-term stability in aqueous and ambient environments for at least 90 days. The bioactive post-modification potential was demonstrated in a proof-of-concept study by immobilizing the photosensitizer
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