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ArticleHealth science reports2025

Dietary Phytochemical Index and Risk of Gallstone Disease: A Case-Control Study.

Zeinab Ghaeminejad, Leyli Zahra Bahreini Boroujeni, Fatemeh Javaheri-Tafti, Seyed Ali Abbas-Hashemi, Azita Hekmatdoost, Moloud Ghorbani, Amir Sadeghi, Zahra Yari

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Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Zeinab GhaeminejadStudent Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.
Leyli Zahra Bahreini BoroujeniStudent Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.
Fatemeh Javaheri-TaftiStudent Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.
Seyed Ali Abbas-HashemiDepartment of Nutritional Sciences, College of Human Sciences Texas Tech University Lubbock Texas USA.
Azita HekmatdoostDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran.
Moloud GhorbaniDepartment of Nutrition, Faculty of medicine Mashhad University of Medical Sciences Mashhad Iran.
Amir SadeghiResearch Institute for Gastroenterology and Liver Diseases of Taleghani Hospital Shahid Beheshti University of Medical Sciences Tehran Iran.
Zahra YariDepartment of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0003-2796-2413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Gallstone disease (GSD), a common gastrointestinal disorder, arises from a combination of genetic and metabolic factors. Its rising prevalence is strongly linked to obesity, insulin resistance, and dyslipidemia, all of which are modifiable through dietary interventions. The dietary phytochemical index (DPI), representing the consumption of bioactive plant-based compounds, may influence GSD risk. This study explored the association between DPI and GSD risk. Methods: This case-control study was conducted on 189 newly diagnosed GSD patients and 342 controls. Dietary intake data were collected using a validated 168-item food frequency questionnaire and DPI was calculated as follow: daily energy obtained from foods rich in phytochemicals (kcal)/total daily energy intake (kcal)) × 100. Phytochemical-rich foods include whole grains, fruits, vegetables, olive oil, legumes, nuts, and seeds. Logistic regression models were applied to compute odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for potential confounders. Results: A significant reduction in GSD cases was observed with increasing DPI scores ( Conclusion: These findings demonstrated a significant inverse association between DPI and the risk of gallstone disease, indicating that phytochemical-rich foods may be protective against gallstone formation.

Indexed as

cholelithiasisdietary phytochemical indexgallstone

Identifiers

PMID40831683
PMCPMC12358934

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