ArticleHealth science reports2025
Heart Rate Variability, Cognitive Performance and Cognitive Impairment in Older Adults: Cross-Sectional Results From the Einstein Aging Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Advances in (Bio)Sensors for Physiological Monitoring: A Special Issue Review.Sensors (Basel, Switzerland) · 2026Article
- Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Aims: Although prior work has examined the relation of heart rate variability (HRV) to cognitive impairment, findings have been inconsistent. The association of cardiac vagal control with cognitive impairment remains unclear. Our goal was to examine the association of high frequency HRV (hf-HRV) with mild cognitive impairment and global cognition in a community-based sample of older adults. Methods: 84 participants (mean age 78.1 SD 5.2 years) wore single lead ECG devices for 6-9 days. HRV in the high (0.15-0.40 Hz, [HF-HRV]) frequency band was derived using power spectral analyses. The cognitive battery included the Montreal Cognitive Assessment (MoCA) to assess global cognition, and two tests per domain for memory, executive, language, visuo-spatial and attention. Mild Cognitive Impairment (MCI) was defined using Jak-Bondi criteria. Domain specific impairment was defined as scores > 1.0 SD below age, sex, education standardized norms on at least one test in a domain. Associations of HF-HRV with cognition were examined using logistic and linear regression adjusted for demographics, diabetes, and hypertension. Results: Participants were 82% female; 39% Non-Hispanic White, 44% Non-Hispanic Black, 25% had MCI. Within domains, impairment was present in 25% (memory), 28.6% (executive function), 21.4% (attention), 17.9% (language), and 27.4% (visuospatial). HF-HRV was inversely associated with prevalent MCI (OR per 1 SD increase in ln HF-HRV: 0.47, Conclusion: Higher hf-HRV, indicative of greater cardiac parasympathetic control is associated with lower odds of MCI, or memory impairment and with better global cognition after adjustment for cardiovascular risk factors. Future longitudinal studies are needed to confirm these associations.
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Registered trials
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