ArticleGynecologic oncology reports2025
Real-world outcomes after pembrolizumab treatment for cervical cancer: Results from a university setting.
Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Real-world effectiveness of pembrolizumab for first-line treatment of metastatic non-small-cell lung cancer: a decade of evidence and experience.Future oncology (London, England) · 2026Review
- Oncological outcome and immune-checkpoint-blockade-induced toxicities in patients with cervical cancer - a Norwegian real-world cohort.Acta oncologica (Stockholm, Sweden) · 2026Article
- Past present and future of radiosensitization in cervical cancer.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To estimate survival among patients with cervical cancer treated with pembrolizumab, examine risk factors for poor outcomes, and assess toxicities in a real-world setting. Methods: This retrospective study included patients treated with pembrolizumab for advanced or recurrent cervical cancer at a tertiary academic center. Data were collected from patients initiating pembrolizumab treatment after May 2018 through June 2023. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method. Associations between patient characteristics and OS were assessed using a Cox model. Results: Forty-four patients were included in the study. Mean age at first pembrolizumab was 51.4 years and 30 % of patients self-identified as non-White. Complete response was seen in 10 patients (23 %). Median OS was 47.5 months (95 % confidence interval (CI), 19.7 to not estimable) and median PFS was 9.1 months (95 % CI, 7.4 to 15.8). Patients with Eastern Cooperative Oncology Group Performance Status (PS) > 1 had a six-fold increased hazard of death compared to PS of 0 or 1 (p =0.0038). Five patients with a PS > 1. Four died of disease progression; one was alive at last follow-up. A total of 22 adverse events occurred, and 7 % were grade 3 or higher. Conclusion: Pembrolizumab is safe and effective for advanced and recurrent cervical cancer in a real-world population. For those with good performance, further study is needed to determine if prolonged complete responses are cures. PS should be considered when making treatment recommendations, as patients with poor PS may not experience the survival benefits shown in pivotal trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.