SynthesisFrontiers in microbiology2025
A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites.
Synthesis in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Noninvasive monitoring of inspiratory effort in mechanical ventilation: a dual-database bibliometric analysis from 1990 to 2025.Frontiers in medicine · 2025Pooled it
- Global research trends in fecal microbiota transplantation combined with immune checkpoint inhibitors for cancer immunotherapy: a bibliometric analysis.Translational cancer research · 2026Article
- Cyberchondria, Psychological Well-Being, Anxiety, and Depression Levels in Female Patients with Irritable Bowel Syndrome.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Metabolites derived from the gut microbiota are substantial contributors to the pathophysiology of Irritable Bowel Syndrome (IBS). As our understanding of the mechanisms underlying gut microbiota metabolites advances, significant progress has been made in research exploring the correlation between gut microbiota metabolites and IBS. Nevertheless, a comprehensive synthesis of research foci and trends in this domain is still lacking. Consequently, integrating scientometric methods with a range of analytical tools can facilitate the identification of key research areas and potential future study directions. Methods: The present study employed scientometric tools, including VOSviewer, Bibliometrix software, CiteSpace, Tableau, and R software, to collect and analyze research literature on IBS and gut microbiota metabolites. This comprised an analysis of journal publications and their impact, the identification of prolific authors, the establishment of national research collaboration networks, and the co-occurrence analysis of keywords. Results: The analysis revealed that, following screening, a total of 1,489 documents were obtained, with a gradual increase in the number of publications starting from 2006. The United States, China, and the United Kingdom have been identified as the primary hubs of this research field. The leading research institutions were identified as University College Cork, the Mayo Clinic, and the University of California. In the domain of research under discussion, John F. Cryan, Timothy G. Dinan, and Gerard Clarke are the most prominent authors. Multiple analyses of the keywords revealed that research on gut microbiota metabolites in irritable bowel syndrome primarily focuses on the functions and mechanisms of action of specific metabolites (1). Emerging research hotspots on gut microbial metabolites influencing IBS are centered on bile acids. In contrast, chain fatty acids have been the most studied metabolites in past research. (2) Gut microbiota metabolites primarily affect IBS through the critical role of the gut-brain axis and are closely associated with anxiety-like behaviors. (3) Experimental types related to gut microbiota metabolites and IBS research. Conclusion: This study employed bibliometric analysis to map the knowledge structure and identify research hotspots in gut microbiota metabolites and IBS, providing insights for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.