ArticleBiomedical reports2025
Comprehensive genomic profiling of Taiwanese triple-negative breast cancer samples with medium- and large-sized sequencing panels: A comparative study implicating treatment allocations.
Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Comprehensive genomic profiling (CGP) is a molecular diagnostic tool with increasing use in cancer research and treatment. There are several commercialized CGP assays with variable targeted genes, while the differences between medium- and large-sized panels in refining genomic profiling strategies, optimizing resource allocation and enhancing clinical applications require evaluation. In the present study, patients with triple-negative breast cancer (TNBC) from the Veterans General Hospital TAipei-Yung-Ling foundation sinO-canceR study were initially assayed using a medium-sized CGP panel (Oncomine comprehensive panel), and the remaining nucleic acid specimens were re-sequenced with a large-sized panel (TruSight Oncology 500). The molecular profiling between the two sequencing panels was compared. A total of 108 breast cancer samples were successfully assayed using both platforms and 272 variants were reported at least once by either type of CGP. The reported variants were among actionable genes (
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