Enhancing Lesion Segmentation in Ultrasound Images: The Impact of Targeted Data Augmentation Strategies.

Automated lesion segmentation in ultrasound (US) images based on deep learning (DL) approaches plays a crucial role in disease diagnosis and treatment. However, the successful implementation of these approaches is conditioned by large-scale and diverse annotated datasets whose obtention is tedious and expertise demanding. Although methods like generative adversarial networks (GANs) can help address sample scarcity, they are often associated with complex training processes and high computational demands, which can limit their practicality and feasibility, especially in resource-constrained scenarios. Therefore, this study is aimed at exploring new solutions to address the challenge of limited annotated samples in automated lesion delineation in US images. Specifically, we propose five distinct mixed sample augmentation strategies and assess their effectiveness using four deep segmentation models for the delineation of two lesion types: breast and thyroid lesions. Extensive experimental analyses indicate that the effectiveness of these augmentation strategies is strongly influenced by both the lesion type and the model architecture. When appropriately selected, these strategies result in substantial performance improvements, with the Dice and Jaccard indices increasing by up to 37.95% and 36.32% for breast lesions and 14.59% and 13.01% for thyroid lesions, respectively. These improvements highlight the potential of the proposed strategies as a reliable solution to address data scarcity in automated lesion segmentation tasks. Furthermore, the study emphasizes the critical importance of carefully selecting data augmentation approaches, offering valuable insights into how their strategic application can significantly enhance the performance of DL models.