Evidence map›Paper›PMID 40831599›Full record

ArticleFrontiers in bacteriology2025

Preclinical validation of electrospun fibers to achieve vaginal colonization by

Christy N Armstrong, Sudeshna Saha, Marnie A Aagard, Mohamed Y Mahmoud, Nissi M Varki, Nicole M Gilbert, Hermann B Frieboes, Warren G Lewis, Amanda L Lewis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christy N ArmstrongDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, California USA.
Sudeshna SahaDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, California USA.
Marnie A AagardDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, California USA.
Mohamed Y MahmoudCenter for Predictive Medicine, University of Louisville, 505 S. Hancock St., Louisville, KY 40202, USA.
Nissi M VarkiGlycobiology Research and Training Center, University of California San Diego, La Jolla, California USA.
Nicole M GilbertDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hermann B FrieboesCenter for Predictive Medicine, University of Louisville, 505 S. Hancock St., Louisville, KY 40202, USA.
Warren G LewisDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, California USA.
Amanda L LewisDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, California USA.

Funding

ROLES OF SIALIDASE IN G. VAGINALIS-HOST INTERACTIONS DURING BACTERIAL VAGINOSISR01AI114635 · NIAID · WASHINGTON UNIVERSITY · PI LEWIS, AMANDA L., LEWIS, WARREN G · 2015 to 2025
$5.9M
3D-bioprinting of sustained- and phased-release antibiotic and probiotic scaffolds to treat bacterial vaginosisR01AI168475 · NIAID · UNIVERSITY OF LOUISVILLE · PI FRIEBOES, HERMANN, LEWIS, AMANDA L. · 2022 to 2025
$3.0M
Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative Intravaginal Delivery Platforms to Treat Bacterial VaginosisR01AI139671 · NIAID · UNIVERSITY OF LOUISVILLE · PI FRIEBOES, HERMANN, LEWIS, AMANDA L. · 2019 to 2023
$2.5M
NIAID NIH HHS R01 AI114635NIAID NIH HHS R01 AI139671NIAID NIH HHS R01 AI168475
6 · The paper itself

Abstract

Communities of bacteria collectively known as the vaginal microbiota reside in the human vagina. Bacterial vaginosis (BV) describes an imbalance of this microbiota, affecting more than 25% of women worldwide, and is linked to health problems such as infertility, cervical cancer, and preterm birth. Following antibiotic treatment, BV becomes recurrent in many individuals.

Indexed as

Bacterial vaginosiselectrospun fibershistopathologylactateLactobacillus crispatusvaginal colonization

Identifiers

PMID40831599
PMCPMC12360433

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.