ArticleRisk management and healthcare policy2025
The Evolving Global Epidemiology of Presenile Dementia in People Aged Under 65: A 40-year Cross-Sectional Study.
Article in Risk management and healthcare policy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dual-task versus single-task walking within an Otago Exercise Program for older adults with dementia: A 24-week cluster randomized controlled trial.Journal of exercise science and fitness · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Despite presenile dementia substantial impact on patients, caregivers, and healthcare systems, comprehensive global assessments of its burden are lacking. This research aims to address this knowledge gap by investigating the trends in the epidemiology of presenile dementia since 1990 and forecast to 2030, providing essential evidence for healthcare policy and resource planning. Methods: This cross-sectional, population-based study leveraged data for individuals aged 40-64 years of presenile dementia from the GBD study, which performed a detailed evaluation related metrics across 204 countries. We calculated age-standardized rates for incidence, mortality, and DALYs. Projections were generated using a Bayesian APC model based on historical trends. SDI quintiles were used to assess disparities across countries. Results: The global age-standardized incidence rate of presenile dementia is expected to rise to 43.97 per 100,000 population by 2030 (EAPC, 0.07 [95% CI: -0.02-0.17]). However, age-standardized death and DALY rates are forecasted to decline to 2.61 (EAPC, -0.01 [95% CI: -0.07-0.05]) and 113.38 per 100,000 (EAPC, -0.05 [95% CI: -0.10-0.00]), respectively. Women are expected to exhibit higher incidence rates than men (47.13 vs 40.94 per 100,000 in 2030), reflecting consistent sex-based disparities. Incidence, death, and DALY rates are projected to continue to rise in low SDI countries. Conclusion: The overall burden of presenile dementia remains substantial due to continued increases in incidence rates, particularly pronounced in low-resource settings. These findings underscore the urgent need for targeted prevention strategies, particularly in low-resource settings, and continued investments in health care infrastructure to address disparities. Expanding screening programs to younger populations globally could help reduce the associated burden of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.