ArticleFrontiers in immunology2025
Characterization of bronchus-associated lymphoid tissue induced by co-exposure to Asian sand dust and ovalbumin: a study using 3D serial section imaging.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Immunological mechanistic action of intravenous BCG-mediated protection against tuberculosis.Cellular and molecular life sciences : CMLS · 2026Review
- Bronchus-associated lymphoid tissue: a review of its development and function, including recent findings on the impact of environmental particulate exposure.Clinical and experimental medicine · 2025Review
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Authors and funding
9 authors.
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Abstract
Introduction: Inducible bronchus-associated lymphoid tissue (iBALT) develops with different morphologies and functions depending on the type of antigen, in which various cytokines, such as interleukin (IL)-1 and IL-17, and the cells producing them, such as T helper 17 (Th17) and T follicular helper (T Methods: B cell clusters were analyzed using the next generation serial section-three-dimensional (nSS3D) imaging method, in which we attempted to introduce batch image acquisition using a high-resolution slide scanner and AI-based image registration and target extraction. Furthermore, the mechanism underlying ASD-induced B-cell cluster formation was examined using CD4-Cre Bcl6 Results: ASD induced B-cell cluster formation in mouse lung tissue, which was enhanced by allergen (Ovalbumin: OVA) exposure. Furthermore, the nSS3D images revealed that a part of the B cell clusters induced by OVA+ASD but not others exhibited common histological features of previously reported iBALTs. Moreover, OVA+ASD exposure failed to induce all of the B cell cluster formation including iBALTs in CD4-Cre Bcl6 Conclusion: B cell clusters including iBALTs are induced by ASD; this process is enhanced by OVA, in which T
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