Evidence map›Paper›PMID 40831523›Full record

ArticleFrontiers in psychiatry2025

Gender differences in neurocognitive impairment among first-episode, drug-naïve schizophrenia patients: a cross-sectional study.

Qing Zhang, AiMin Sui, Min Su, MingLiang Ju, YanYan Wei, XiaoChen Tang, LiHua Xu, HuiRu Cui, YingYing Tang, ZhengHui Yi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qing Zhang *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
AiMin Sui *Department of Psychiatry, Taizhou Second People's Hospital, Zhejiang, China.
Min Su *Department of Psychiatry, Ningde Rehabilitation Hospital, Fujian, China.
MingLiang JuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
YanYan WeiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
XiaoChen TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
LiHua XuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
HuiRu CuiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
YingYing TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
ZhengHui YiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
HaiChun LiuDepartment of Automation, Shanghai Jiao Tong University, Shanghai, China.
Jin GaoDepartment of Clinical Psychology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
JiJun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
TianHong ZhangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cognitive impairment is a core feature of first-episode schizophrenia (FES), yet the influence of biological sex on its manifestation remains under characterized. Existing evidence suggests sex differences in cognitive profiles among chronic schizophrenia patients, but whether these patterns emerge in drug-naïve FES patients-and how they relate to clinical symptoms-requires clarification. Methods: We recruited 382 drug-naïve FES patients and 522 healthy controls (HCs) matched for age and education. Cognitive function was assessed using the MATRICS Consensus Cognitive Battery (MCCB). Clinical symptoms were evaluated via the Positive and Negative Syndrome Scale (PANSS). Results: FES patients demonstrated global cognitive deficits compared to HCs. When stratified by diagnostic group (FES and HC), males outperformed females in planning and problem-solving, as measured by the Neuropsychological Assessment Battery Mazes subtest ( Conclusion: FES manifests as sex-divergent cognitive profiles, with males showing executive/processing speed deficits tied to negative symptoms and females exhibiting memory impairments with broader symptom associations. These findings underscore the need for sex-sensitive approaches in characterizing cognitive dysfunction in early psychosis.

Indexed as

cognitionfirst-episodegenderpsychosisschizophrenia

Identifiers

PMID40831523
PMCPMC12358438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.