ArticleResearch square2025
Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease.
Anna Goodheart, Chi-Hyeon Yoo, Aline Fassini, Tewodros Dagnew, Rong Ye, Robin Striar, Moqing Quan, Anna Rattray, Tyler Meyer, Erin Peterec and 6 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Anna GoodheartMassachusetts General Hospital.
Chi-Hyeon YooMassachusetts General Hospital.
Aline FassiniMassachusetts General Hospital.
Tewodros DagnewMassachusetts General Hospital.
Rong YeMassachusetts General Hospital.
Robin StriarMassachusetts General Hospital.
Moqing QuanMassachusetts General Hospital.
Anna RattrayMassachusetts General Hospital.
Tyler MeyerMassachusetts General Hospital.
Erin PeterecMassachusetts General Hospital.
Han LeeMassachusetts General Hospital.
Stephanie FiedlerMassachusetts General Hospital.
Jacob HookerMassachusetts General Hospital.
Hsiao-Ying WeyMassachusetts General Hospital.
Changning WangMassachusetts General Hospital.
Stephen GompertsMassachusetts General Hospital.
Funding
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5MImaging epigenetic dysregulation in the Lewy body dementias with [11C]MartinostatR01AG082331 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Stephen N. Gomperts, Changning Wang · 2023 to 2026
$3.3MImaging Epigenetic Mechanisms in the Lewy Body Dementias with [11C]MartinostatR56AG070827 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOMPERTS, STEPHEN N., WANG, CHANGNING · 2021 to 2021
$776kMRI-Compatible PET Insert for Small Bore ScannerS10OD023503 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2017 to 2017
$600kCarbon-11 Automation Equipment for Human PET Radiotracer ProductionS10OD023517 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2018 to 2018
$502kImaging Epigenetic Mechanisms in Parkinson's Disease with [11C]MartinostatR21NS109833 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GOMPERTS, STEPHEN N., WANG, CHANGNING · 2018 to 2019
$463kNIA NIH HHS P30 AG062421NIA NIH HHS R01 AG082331NIA NIH HHS R56 AG070827NIH HHS S10 OD023503NIH HHS S10 OD023517NINDS NIH HHS R21 NS109833
6 · The paper itselfAbstract
Background: Histone deacetylases (HDACs) are epigenetic molecules responsible for regulation of gene transcription. Altered expression of HDACs has been linked to neurodegenerative disease. Here, we used the class I HDAC PET radioligand [ Results: Compared to HC, [ Conclusions: These findings reveal evidence of elevated class I HDACs in motor cortex in PD and bidirectional changes in their regional expression in the Lewy body dementias.
Indexed as
dementia with Lewy bodiesHistone deacetylaseLewy body dementiaMartinostatParkinson’s disease
Identifiers
PMID40831509
PMCPMC12363930
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