ArticleResearch square2025
Familial co-aggregation and shared heritability between clinically diagnosed neurodevelopmental problems and cardiometabolic conditions: a nationwide register study across three generations.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Neurodevelopmental conditions such as attention-deficit/hyperactivity disorder (ADHD) and autism co-occur with cardiometabolic conditions. However, little is known about the mechanisms underlying this co-occurrence. In this nationwide three-generation study using population-based registers in the Netherlands (n=15 million), we assessed the familial (co-)aggregation of ADHD, autism, and cardiometabolic conditions, and estimated their heritabilities and genetic correlations. ADHD, autism, and cardiometabolic conditions showed aggregation and co-aggregation within families and between spouses. Estimated heritabilities of ADHD and autism were moderate (both
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