Evidence map›Paper›PMID 40831508›Full record

ArticleResearch square2025

Familial co-aggregation and shared heritability between clinically diagnosed neurodevelopmental problems and cardiometabolic conditions: a nationwide register study across three generations.

Yiran Li, Yiling Zhou, Melissa Vos, Martje Bos, Olivier Steen, Naomi R Wray, Catharina A Hartman, Harold Snieder

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiran LiInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0002-4704-8728
Yiling ZhouDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Melissa VosInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0002-4777-6338
Martje BosInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Olivier SteenInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0002-6278-3106
Naomi R WrayDepartment of Psychiatry and Big Data Institute, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-7421-3357
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0003-1949-2298

Funding

An Integrative Approach to the Etiology of Internalizing Disorders in the Lifelines CohortR01MH125902 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENNETH SEEDMAN KENDLER, Hanna van Loo · 2022 to 2026
$2.8M
NIMH NIH HHS R01 MH125902
6 · The paper itself

Abstract

Neurodevelopmental conditions such as attention-deficit/hyperactivity disorder (ADHD) and autism co-occur with cardiometabolic conditions. However, little is known about the mechanisms underlying this co-occurrence. In this nationwide three-generation study using population-based registers in the Netherlands (n=15 million), we assessed the familial (co-)aggregation of ADHD, autism, and cardiometabolic conditions, and estimated their heritabilities and genetic correlations. ADHD, autism, and cardiometabolic conditions showed aggregation and co-aggregation within families and between spouses. Estimated heritabilities of ADHD and autism were moderate (both

Identifiers

PMID40831508
PMCPMC12363924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.