Evidence map›Paper›PMID 40831505›Full record

ArticleResearch square2025

Unc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma.

Marilena Tauro, Tao Li, Praneeth R Sudalagunta, Mark Meads, Rafael Renatino Canevarolo, Niveditha Nerlakanti, Raghunandan R Alugubelli, Harshani R Lawrence, Steven Gunawan, Mohammad Ayaz and 13 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Marilena TauroDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Tao LiDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.ORCID 0000-0002-2681-0429
Praneeth R SudalaguntaDepartment of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Mark MeadsDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Rafael Renatino CanevaroloDepartment of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Niveditha NerlakantiDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.ORCID 0000-0001-8808-2220
Raghunandan R AlugubelliDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL, USA.
Harshani R LawrenceChemical Biology Core, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Steven GunawanDrug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Mohammad AyazDrug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Pradeep NareddyDrug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Sang Young YunDrug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Gemma ShayDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Kathy YangChemical Biology Core, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Timothy H TranChemical Biology Core, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.ORCID 0000-0003-1342-7620
Ryan T BishopDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Mostafa M NasrDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Nicholas N J LawrenceDrug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.ORCID 0000-0003-1129-2558
Ernst SchönbrunnDrug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
John L ClevelandDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.ORCID 0000-0002-7561-9065
Ariosto S SilvaCancer Biology Ph.D. Program, University of South Florida; Tampa, FL, USA.ORCID 0000-0003-3237-9986
Kenneth H ShainDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.
Conor C LynchDepartment of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute; Tampa, FL, USA.ORCID 0000-0002-4506-6244

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Developing Chemical Probes for Oncogenic Signaling PathwaysR50CA211447 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Harshani R Lawrence · 2017 to 2026
$2.2M
Role of ULK3 in Sensitive and Refractory Multiple MyelomaR01CA269721 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Conor C Lynch · 2023 to 2026
$2.1M
An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA269721NCI NIH HHS R50 CA211447NIH HHS S10 OD030394
6 · The paper itself

Abstract

Despite the availability of effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. To identify new therapeutic targets, we assessed RNA sequencing data from CD138

Identifiers

PMID40831505
PMCPMC12363935

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.