Evidence map›Paper›PMID 40831501›Full record

ArticleResearch square2025

Analysis of Systolic Cardiac Function in PERM1-knockout Mice: Insights from A Retrospective Study in Large Cohorts of Animals.

Alexey V Zaitsev, Karthi Sreedevi, Brianna Goode, Junco S Warren

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alexey V ZaitsevFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech.
Karthi SreedeviFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech.
Brianna GoodeFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech.
Junco S WarrenFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech.

Funding

Perm1 is a Novel Regulator of Cardiac Energetics and FunctionR01HL156667 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DRAKOS, STAVROS GEORGE, WARREN, JUNKO SHIBAYAMA · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL156667
6 · The paper itself

Abstract

Several groups demonstrated that PERM1 is a positive regulator of mitochondrial bioenergetics in the heart. However, discrepant results have emerged with regard to whether PERM1 loss-of-function affect cardiac contractility. Here we present data from a retrospective study collecting echocardiography data from all

Indexed as

cardiac contractilityechocardiographyejection fractionPERM1power analysis

Identifiers

PMID40831501
PMCPMC12363925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.