Evidence map›Paper›PMID 40831499›Full record

ArticleResearch square2025

Charles W Ryan, Samantha L Regan, Jason B Sheingold, Anupam Goswami, Maureen Mulhern, Jonathan Ploeger, Samuel Huang, Verity Hartill, Alyssa Rippert, Elizabeth Bhoj and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Charles W RyanCellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI, 48109-5618, USA.ORCID 0000-0001-7476-9099
Samantha L ReganDepartment of Human Genetics, University of Michigan Medical School, 3703 Med Sci II, 1241 E. Catherine St., Ann Arbor, MI, 48109-5618, USA.ORCID 0000-0001-9198-1411
Jason B SheingoldDepartment of Human Genetics, University of Michigan Medical School, 3703 Med Sci II, 1241 E. Catherine St., Ann Arbor, MI, 48109-5618, USA.ORCID 0009-0007-5248-865X
Anupam GoswamiMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, U.P., India.
Maureen MulhernDepartment of Neurology, Columbia University Medical Center, Columbia University, New York, NY, USA.
Jonathan PloegerMarshfield Medical Center, Marshfield Clinic Health Center, Marshfield, WI, USA.
Samuel HuangMarshfield Medical Center, Marshfield Clinic Health Center, Marshfield, WI, USA.
Verity HartillDepartment of Clinical Genetics, Chapel Allerton Hospital, Leeds Teaching Hospitals, NS Foundation Trust, Leeds, UK.
Alyssa RippertDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elizabeth BhojDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3438-5685
Jennifer BainDepartment of Neurology, Columbia University Medical Center, Columbia University, New York, NY, USA.ORCID 0000-0002-6642-8902
Kinshuk Raj SrivastavaMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, U.P., India.
Stephanie L BielasMedical Science Training Program, University of Michigan Medical School, 3703 Med Sci II, 1241 E. Catherine St., Ann Arbor, MI, 48109-5618, USA.ORCID 0000-0003-0567-5632

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Prospective Genetic Risk Evaluation and Assessment (PROGRESS) in AutismP50HD109879 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung · 2022 to 2026
$14.0M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Michigan Predoctoral Training in GeneticsT32GM149391 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN V. MORAN · 2024 to 2026
$2.2M
Role of histone ubiquitination in neurodevelopment and diseaseR01NS101597 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BIELAS, STEPHANIE LEE · 2018 to 2022
$2.0M
CTSA Postdoctoral T32 at the University of MichiganT32TR004764 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, Steven Edward Harte · 2024 to 2026
$1.4M
PRC1-dependent H2A Monoubiquitination During Human CorticogenesisF31NS127551 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RYAN, CHARLES WILLIAM · 2023 to 2024
$58k
NCATS NIH HHS T32 TR004764NCI NIH HHS P30 CA046592NICHD NIH HHS P50 HD109879NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM007863NIGMS NIH HHS T32 GM149391NINDS NIH HHS F31 NS127551NINDS NIH HHS R01 NS101597
6 · The paper itself

Abstract

Polycomb Repressive Complex 1 (PRC1) catalyzes H2AK119ub1 to facilitate transcriptional repression during development.

Identifiers

PMID40831499
PMCPMC12363927

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.