ArticleJournal of investigative medicine high impact case reports
Central Nervous System Toxoplasmosis in the Setting of Mycophenolate Mofetil Monotherapy for Autoimmune Hepatitis.
Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Central nervous system (CNS) toxoplasmosis is a life-threatening opportunistic infection most often reported in patients with HIV/AIDS and solid organ transplantation. Its occurrence in immunocompetent patients is rare and even less commonly reported in those receiving single-agent immunosuppressive therapy. We present a unique case of CNS toxoplasmosis in a 68-year-old seropositive female with autoimmune hepatitis maintained on long-term mycophenolate mofetil (MMF) monotherapy. She presented with a 2-day history of confusion and expressive aphasia, without fever or focal neurologic deficits. Brain MRI revealed multiple ring-enhancing lesions, prompting a broad differential diagnosis including malignancy, abscess, and demyelination. A stereotactic biopsy confirmed necrotic tissue harboring
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