Evidence map›Paper›PMID 40831403›Full record

ReviewHistopathology2025

Pathology reporting of hepatoblastoma resections: recommendations from the international collaboration on cancer reporting.

Dolores H López-Terrada, Fleur Webster, Rita Alaggio, Jonathan W Bush, Soo-Jin Cho, Ronald R de Krijger, Takeshi Inoue, Allison F O'Neill, Antonio R Perez-Atayde, Sarangarajan Ranganathan and 4 more

Abstract readReview
In one paragraph

Review in Histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dolores H López-TerradaDepartment of Pathology, Texas Children's Hospital, Houston, TX, USA.ORCID https://orcid.org/0000-0002-6584-420X
Fleur WebsterInternational Collaboration on Cancer Reporting, Surry Hills, NSW, Australia.ORCID https://orcid.org/0000-0001-8706-0388
Rita AlaggioPathology Unit, Department of Laboratories, Bambino Gesu Children's Hospital IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0003-3915-3816
Jonathan W BushDepartment of Pathology, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0001-9432-2390
Soo-Jin ChoDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-6324-6858
Ronald R de KrijgerDepartment of Pathology, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-6871-1296
Takeshi InoueDepartment of Pathology, Osaka City General Hospital, Osaka City, Japan.ORCID https://orcid.org/0009-0000-6242-6400
Allison F O'NeillDepartment of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-8957-3870
Antonio R Perez-AtaydeDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-8036-6288
Sarangarajan RanganathanDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID https://orcid.org/0000-0001-6214-9167
Jens StahlschmidtDepartment of Histopathology and Molecular Pathology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID https://orcid.org/0000-0002-2234-0271
Yukichi TanakaDepartment of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.ORCID https://orcid.org/0000-0003-1145-5249
Marta CohenDepartment of Pathology, Sheffield Children's Hospital NHS F.T., University of Sheffield, Western Bank, Sheffield, UK.ORCID https://orcid.org/0000-0001-5534-444X
Miguel Reyes-MúgicaDepartment of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Coral Gables, FL, USA.ORCID https://orcid.org/0000-0001-5698-3702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHepatoblastoma is the most common primary malignant tumour of the liver diagnosed in children and its incidence is increasing worldwide. Ongoing international clinical trials and scientific collaborative efforts are attempting to standardize the diagnosis, risk stratification and management of young patients diagnosed with this rare cancer, which includes surgical resection of the tumour. Here we report the international consensus-based dataset for the pathology reporting of hepatoblastoma resection specimens. The dataset was developed under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of international pathology and cancer organizations. METHODS AND

resultsAccording to the ICCR's guidelines for dataset development, an international expert panel including paediatric pathologists and a paediatric oncologist specialized in liver tumours developed a set of core and non-core data items for hepatoblastoma resection specimens based on critical review and discussion of current evidence available. Members of the panel were specialists working in tertiary paediatric hospitals, central reviewers for international paediatric liver tumours consortia and/or involved in paediatric liver tumour trials expert committees. Commentaries were provided to support each data item, explaining the rationale for selecting them as a 'core' or 'non-core' elements, their clinical relevance and highlighting potential areas of lack of evidence, including clinical, macroscopic, microscopic and ancillary testing considerations. The hepatoblastoma dataset was finalized and ratified following international public consultation and is published on the ICCR website for wide implementation.

conclusionThis is the first international dataset developed by an international expert panel for reporting hepatoblastoma resection specimens aimed to promote high-quality, standardized pathology reporting of these rare paediatric liver tumours. The adoption and implementation of this hepatoblastoma data set, freely available worldwide on the ICCR website (www.iccr-cancer.org/data-sets), will facilitate accurate reporting and enhance the consistency of data collection, support retrospective and inform prospective research and ultimately help to improve clinical outcomes of children with hepatoblastoma.

Indexed as

HepatoblastomaLiver NeoplasmsChildHumansInternational CooperationchecklistdatasethepatoblastomaICCR guidelinesliver tumourspaediatricsprotocolstructured reportsynoptic report

Identifiers

PMID40831403
PMCPMC12605668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.