ArticleMovement disorders clinical practice2025
Cognitive Fluctuation Scale in Non-demented Patients with Parkinson's Disease.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundCognitive fluctuations (CF) are spontaneous alterations in cognition, attention, and arousal, which are core clinical features in Lewy body dementia. A 4-item scale from the Dementia Cognitive Fluctuation Scale (4-item DCFS) is used in demented patients to identify CF. However, this has not been applied to non-demented patients with Parkinson's disease (PD).
objectivesWe applied the 4-item DCFS in non-demented PD patients to evaluate its relationship to neuropsychological tests and to determine whether this score is associated with cognitive deterioration.
methodsFifty-one patients underwent prospective neuropsychological assessments. Those who scored ≥3 in the 4-item DCFS were recognized as CF positive. The Bayesian Kendall correlation test was applied to assess the relationship between the 4-item DCFS score, cognitive tests, and amyloid burden. Forty-five patients were followed up for 3 years.
resultsThirty-two patients scored 0 (62.7%, no positive answers), 11 (21.6%) scored 1, 4 (7.8%) scored 2, and 4 (7.8%) scored 3 points on the 4-item DCFS. Moderate or strong evidence showed that the 4-item-DCFS score correlated with worse performance on the Trail Making Test B (Bayes factor, BF
conclusionsA higher score on the 4-item DCFS is related to lower scores in executive and memory function, along with a potential connection to amyloid pathology. Patients with lower scores are less likely to develop a worse cognitive state, although larger sample sizes are needed to confirm this relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.