ArticleAnnals of medicine2025
Intravenous lidocaine as an adjuvant to propofol sedation for elderly patients undergoing same-visit bidirectional endoscopy: protocol for a multicenter randomized controlled trial.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSame-visit bidirectional endoscopic procedures under sedation are frequently performed in elderly patients. However, the optimal sedation regimen for elderly patients remains uncertain. This study seeks to evaluate the hypothesis that intravenous lidocaine, when used as an adjunct to propofol sedation, reduces the incidence of sedation-related adverse events during these procedures.
methodsThis multicenter, randomized, double-blind, placebo-controlled trial will enroll 648 elderly patients scheduled for same-visit bidirectional endoscopy under sedation at four hospitals in China. Participants will be randomized in a 1:1 ratio to receive either intravenous lidocaine or normal saline (placebo), stratified by study center ( DISCUSSION: We hypothesize that adjunctive lidocaine with propofol-based sedation will reduce the incidence of intraoperative desaturation and hypotension in elderly patients undergoing same-visit bidirectional endoscopy. The findings will contribute to optimizing sedation strategies in this vulnerable population.
trial registrationChinese Clinical Trial Registry (ChiCTR2400087583).
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